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The career, philanthropic, political, and personal aspects of Charles Richard Crane's life were closely intertwined. Among the correspondence of significance in the papers are letters to and from James Francis Abbott, Kathryn Newell Adams, Jane Addams, Edmund Henry Hynman Allenby, Edvard Benes, Boris III, King of Bulgaria, Louis Dembitz Brandeis, Nicholas Murray Butler, Frances F. Cleveland, Grover Cleveland, Archibald Gary Coolidge, Calvin Coolidge, John Dewey, Charles William Elliot, Hamlin Garland, William Rainey Harper, Jean-Jules Jusserand, William Lyon Mackenzie King, Alexander Kuprin, Robert Marion LaFollette, Seth Low, William Gibbs McAdoo, Jan Masaryk, Tomas Masaryk, Pavel Miliukov, John Pierpont Morgan, Alphonse Maria Mucha, Fridtjof Nansen, George Haven Putnam, John Davison Rockefeller Jr., Theodore Roosevelt, Upton Beall Sinclair, William Howard Taft, Lillian D. Wald, Herbert George Wells, Edith B. Wilson, Woodrow Wilson and other.

The collection consists of the records of university seminars in various fields for each academic year since their establishment. A typical file will include minutes of the meetings, but there may also be supporting documentation such as correspondence, reports, or copies of papers presented at a meeting.

Correspondence, manuscripts, lectures, notes, diaries, notebooks, reports, financial records, blueprints, photographs, and printed materials of Y.C. James Yen and the IIRR concerned with the development, sharing, and financing innovative methods of teaching, improving agriculture, health and family planning, and education in impoverished villages. Among the cataloged correspondents are: Pearl Buck, William O. Douglas, Nelson Rockefeller, and DeWitt Clinton.